Alpha 1-antichymotrypsin

SERPINA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AS4, 1QMN, 2ACH, 3CAA, 3DLW, 4CAA
Identifiers
Aliases	SERPINA3, AACT, ACT, GIG24, GIG25, serpin family A member 3
External IDs	OMIM: 107280; MGI: 98377; HomoloGene: 111129; GeneCards: SERPINA3; OMA:SERPINA3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,624,055 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,312,403 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; islet of Langerhans; ; gastric mucosa; ; left coronary artery; ; right coronary artery; ; gallbladder; ; left uterine tube; ; right lung; ; right ovary;
	Top expressed in
	left lobe of liver; ; sexually immature organism; ; pharynx; ; parotid gland; ; spinal ganglia; ; basal plate; ; medial head of gastrocnemius muscle; ; adrenal gland; ; white adipose tissue; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; DNA binding; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	blood microparticle; extracellular exosome; intracellular anatomical structure; nucleus; platelet alpha granule lumen; extracellular region; extracellular space; secretory granule lumen; azurophil granule lumen; collagen-containing extracellular matrix;
Biological process	regulation of lipid metabolic process; negative regulation of peptidase activity; inflammatory response; maintenance of gastrointestinal epithelium; acute-phase response; platelet degranulation; negative regulation of endopeptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	12
	20714
	ENSG00000196136
	ENSMUSG00000058207
	P01011
	P07759
	NM_001085
	NM_011458
	NP_001076
	NP_035588
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha 1-antichymotrypsin (symbol α₁AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene.