Kallistatin

SERPINA4
Identifiers
Aliases	SERPINA4, KAL, KLST, KST, PI-4, PI4, kallistatin, serpin family A member 4
External IDs	OMIM: 147935; HomoloGene: 48412; GeneCards: SERPINA4; OMA:SERPINA4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,569,913 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; gallbladder; ; islet of Langerhans; ; corpus epididymis; ; caput epididymis; ; body of stomach; ; seminal vesicula; ; tail of epididymis; ; tibialis anterior muscle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular exosome; platelet dense granule lumen; extracellular space; extracellular region;
Biological process	negative regulation of peptidase activity; platelet degranulation; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	5267
	n/a
	ENSG00000100665
	n/a
	P29622
	n/a
	NM_006215; NM_001289032; NM_001289033
	n/a
	NP_001275961; NP_001275962; NP_006206
	n/a
	Wikidata
View/Edit Human

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene.

Kallistatin consists of three folded ß segments and eight helical structures and contains two functional domains, an active site and a heparin-binding site.

Kallistatin signals through several receptors, including integrin ß3, lipoprotein receptor-related protein 6 ( LRP6 ), nucleolin, and Krüppel-like factor 4 ( KLF4 ).