Protein C inhibitor

SERPINA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DY0, 1LQ8, 2HI9, 2OL2
Identifiers
Aliases	SERPINA5, PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI, serpin family A member 5
External IDs	OMIM: 601841; MGI: 107817; HomoloGene: 20159; GeneCards: SERPINA5; OMA:SERPINA5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,593,118 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,072,396 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; right testis; ; left testis; ; left adrenal cortex; ; gallbladder; ; seminal vesicula; ; right lobe of liver; ; body of pancreas; ; human kidney; ; spleen;
	Top expressed in
	spermatocyte; ; epithelium of bronchiole; ; seminiferous tubule; ; urethra; ; spermatid; ; Gonadal ridge; ; mucosa of large intestine; ; embryo; ; epithelium of anal canal; ; mucosa of esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; retinoic acid binding; heparin binding; phosphatidylcholine binding; glycosaminoglycan binding; acrosin binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	platelet alpha granule; protein C inhibitor-TMPRSS11E complex; platelet dense tubular network; protein C inhibitor-plasma kallikrein complex; membrane; protein C inhibitor-PLAU complex; protein C inhibitor-coagulation factor Xa complex; acrosomal membrane; protein C inhibitor-thrombin complex; protein C inhibitor-coagulation factor XI complex; extracellular region; protein C inhibitor-KLK3 complex; protein C inhibitor-coagulation factor V complex; protein C inhibitor-TMPRSS7 complex; protein C inhibitor-PLAT complex; extracellular exosome; external side of plasma membrane; extracellular space; protein-containing complex; collagen-containing extracellular matrix;
Biological process	negative regulation of proteolysis; fusion of sperm to egg plasma membrane involved in single fertilization; negative regulation of peptidase activity; lipid transport; blood coagulation; negative regulation of hydrolase activity; single fertilization; spermatogenesis; negative regulation of endopeptidase activity; seminal vesicle development; transport;
	Sources:Amigo / QuickGO
Orthologs
	5104
	268591
	ENSG00000188488
	ENSMUSG00000041550
	P05154
	P70458
	NM_000624
	NM_172953
	NP_000615
	NP_766541
	Wikidata
View/Edit Human	View/Edit Mouse

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) that limits the activity of protein C (an anticoagulant).

An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.

Protein C inhibitor is activated by heparin against thrombin.

Protein C inhibitor (PCI) is serine protease inhibitor of serpin type that is found in most tissues and fluids, including blood plasma, seminal plasma and urine of human. It is a 52kD glycoprotein and belongs to serine protease inhibitor ( Serpin) super family of protein. In the beginning protein C Inhibitor (PCI) was identified as an inhibitor of activated protein C (APC), it is currently clear that this inhibitor has an expansive specificity, inhibiting several blood coagulation enzymes counting thrombin and factor Xa.