SERPINB1

SERPINB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GA7
Identifiers
Aliases	SERPINB1, EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2, HEL-S-27, serpin family B member 1
External IDs	OMIM: 130135; MGI: 1913472; HomoloGene: 133768; GeneCards: SERPINB1; OMA:SERPINB1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,841,959 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	33,035,168 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; oral cavity; ; bone marrow; ; monocyte; ; palpebral conjunctiva; ; body of pancreas; ; jejunal mucosa; ; trabecular bone; ; bone marrow cells; ; duodenum;
	Top expressed in
	granulocyte; ; left colon; ; jejunum; ; duodenum; ; mucous cell of stomach; ; esophagus; ; tibiofemoral joint; ; epithelium of stomach; ; ileum; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity; protein binding;
Cellular component	cytoplasm; extracellular exosome; membrane; extracellular space; secretory granule lumen; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of peptidase activity; negative regulation of endopeptidase activity; neutrophil degranulation; type B pancreatic cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1992
	66222
	ENSG00000021355
	ENSMUSG00000044734
	P30740
	Q9D154
	NM_030666
	NM_025429
	NP_109591
	NP_079705
	Wikidata
View/Edit Human	View/Edit Mouse

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.

MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.