Plasminogen activator inhibitor-2

SERPINB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ARR, 1BY7, 1JRR, 2ARQ
Identifiers
Aliases	SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2, serpin family B member 2
External IDs	OMIM: 173390; MGI: 97609; HomoloGene: 20571; GeneCards: SERPINB2; OMA:SERPINB2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,903,888 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	107,463,208 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; mucosa of pharynx; ; skin of thigh; ; oral cavity; ; skin of hip; ; decidua; ; epithelium of nasopharynx; ; skin of arm; ; islet of Langerhans; ; gums;
	Top expressed in
	skin of external ear; ; esophagus; ; skin of back; ; lip; ; skin of abdomen; ; granulocyte; ; superior surface of tongue; ; umbilical cord; ; epidermis; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; plasma membrane; extracellular space; cytoplasm;
Biological process	negative regulation of peptidase activity; wound healing; negative regulation of apoptotic process; fibrinolysis; negative regulation of endopeptidase activity; interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5055
	18788
	ENSG00000197632
	ENSMUSG00000062345
	P05120
	P12388
	NM_002575; NM_001143818
	NM_001174170; NM_011111
	NP_001137290; NP_002566
	NP_001167641; NP_035241
	Wikidata
View/Edit Human	View/Edit Mouse

Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tissue plasminogen activator and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.

It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.