SERPINB9

SERPINB9
Identifiers
Aliases	SERPINB9, CAP-3, CAP3, PI-9, PI9, serpin family B member 9
External IDs	OMIM: 601799; MGI: 106603; HomoloGene: 37888; GeneCards: SERPINB9; OMA:SERPINB9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,903,309 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	33,201,940 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; mononuclear cell; ; monocyte; ; germinal epithelium; ; appendix; ; lymph node; ; placenta; ; tibial nerve; ; blood; ; granulocyte;
	Top expressed in
	right lung lobe; ; gastrula; ; left lung; ; mesenteric lymph nodes; ; left lung lobe; ; placenta; ; lumbar spinal ganglion; ; Epithelium of choroid plexus; ; carotid body; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protease binding; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	cytosol; membrane; intracellular anatomical structure; extracellular exosome; nucleus; cytoplasm; extracellular space; nucleoplasm; Golgi apparatus; collagen-containing extracellular matrix;
Biological process	negative regulation of peptidase activity; mast cell mediated immunity; negative regulation of apoptotic process; protection from natural killer cell mediated cytotoxicity; cellular response to estrogen stimulus; positive regulation of gene expression; negative regulation by symbiont of host apoptotic process; immune response; negative regulation of endopeptidase activity; apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5272
	20723
	ENSG00000170542
	ENSMUSG00000045827
	P50453
	O08797
	NM_004155
	NM_009256
	NP_004146; NP_004146.1
	NP_033282
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T lymphocytes and natural killer (NK) cells to induce apoptosis in target cells during an immune response. Serpin B9, expressed in the cytosol and nucleus, thus protects from apoptosis by cytotoxic T lymphocytes and NK cells.

Serpin B9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]