SERPINE2

SERPINE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DY0, 4DY7
Identifiers
Aliases	SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2
External IDs	OMIM: 177010; MGI: 101780; HomoloGene: 21247; GeneCards: SERPINE2; OMA:SERPINE2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	224,039,318 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	79,838,897 bp
RNA expression pattern
	Top expressed in
	decidua; ; cartilage tissue; ; stromal cell of endometrium; ; ventral tegmental area; ; tibia; ; paraflocculus of cerebellum; ; spinal ganglia; ; external globus pallidus; ; trigeminal ganglion; ; superior vestibular nucleus;
	Top expressed in
	seminal vesicula; ; tunica media of zone of aorta; ; calvaria; ; stroma of bone marrow; ; cumulus cell; ; olfactory epithelium; ; tibiofemoral joint; ; body of femur; ; ventral tegmental area; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; glycosaminoglycan binding; peptidase inhibitor activity; heparin binding; serine-type endopeptidase inhibitor activity; signaling receptor binding;
Cellular component	extracellular vesicle; extrinsic component of external side of plasma membrane; platelet alpha granule; extracellular matrix; cytosol; neuromuscular junction; extracellular region; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of cell growth; seminal vesicle epithelium development; secretory granule organization; innervation; mating plug formation; nervous system development; detection of mechanical stimulus involved in sensory perception; multicellular organism development; regulation of cell migration; long-term potentiation; regulation of timing of cell differentiation; cell differentiation; negative regulation of proteolysis; negative regulation of protein catabolic process; negative regulation of plasminogen activation; cerebellar granular layer morphogenesis; negative regulation of cell population proliferation; secretion by cell; negative regulation of sodium ion transport; negative regulation of smoothened signaling pathway; negative regulation of protein processing; positive regulation of astrocyte differentiation; negative regulation of platelet activation; response to wounding; regulation of synaptic transmission, glutamatergic; negative regulation of peptidase activity; negative regulation of blood coagulation; blood coagulation; negative regulation of platelet aggregation; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	5270
	20720
	ENSG00000135919
	ENSMUSG00000026249
	P07093
	Q07235
	NM_001136528; NM_001136530; NM_006216
	NM_009255
	NP_001130000; NP_001130002; NP_006207
	NP_033281
	Wikidata
View/Edit Human	View/Edit Mouse

Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.