PEDF

SERPINF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IMV
Identifiers
Aliases	SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1
External IDs	OMIM: 172860; MGI: 108080; HomoloGene: 1965; GeneCards: SERPINF1; OMA:SERPINF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,777,565 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,313,527 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; pericardium; ; canal of the cervix; ; left uterine tube; ; gallbladder; ; periodontal fiber; ; vena cava; ; right ovary; ; right lobe of liver; ; gastric mucosa;
	Top expressed in
	calvaria; ; molar; ; body of femur; ; ankle; ; left lobe of liver; ; aortic valve; ; ascending aorta; ; stroma of bone marrow; ; lip; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular matrix; melanosome; extracellular region; basement membrane; axon; soma; perinuclear region of cytoplasm; axon hillock; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	cellular response to retinoic acid; kidney development; ageing; response to arsenic-containing substance; negative regulation of gene expression; cellular response to dexamethasone stimulus; negative regulation of endothelial cell migration; multicellular organism development; cellular response to cobalt ion; retina development in camera-type eye; short-term memory; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of neuron projection development; ovulation cycle; negative regulation of angiogenesis; cell population proliferation; negative regulation of inflammatory response; cellular response to glucose stimulus; response to acidic pH; negative regulation of neuron death; negative regulation of endopeptidase activity; positive regulation of neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5176
	20317
	ENSG00000132386; ENSG00000282307
	ENSMUSG00000000753
	P36955
	P97298
	NM_002615; NM_001329903; NM_001329904; NM_001329905
	NM_011340
	NP_001316832; NP_001316833; NP_001316834; NP_002606
	NP_035470
	Wikidata
View/Edit Human	View/Edit Mouse

Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in vertebrates, this 50 kDa protein is being researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease, and cancer. In humans, pigment epithelium-derived factor is encoded by the SERPINF1 gene.