SESN2

SESN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DJ4, 5CUF
Identifiers
Aliases	SESN2, HI95, SES2, SEST2, sestrin 2
External IDs	OMIM: 607767; MGI: 2651874; HomoloGene: 12873; GeneCards: SESN2; OMA:SESN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,282,491 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,237,812 bp
RNA expression pattern
	Top expressed in
	right ovary; ; gonad; ; left ovary; ; stromal cell of endometrium; ; mucosa of transverse colon; ; right lobe of liver; ; duodenum; ; blood; ; islet of Langerhans; ; human kidney;
	Top expressed in
	granulocyte; ; right kidney; ; calvaria; ; proximal tubule; ; stroma of bone marrow; ; yolk sac; ; Rostral migratory stream; ; spermatocyte; ; lip; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; oxidoreductase activity, acting on peroxide as acceptor; leucine binding; sulfiredoxin activity; oxidoreductase activity; GDP-dissociation inhibitor activity;
Cellular component	nucleus; mitochondrion; cytosol; cytoplasm; GATOR2 complex; nucleotide-activated protein kinase complex; Atg1/ULK1 kinase complex; TORC2 complex;
Biological process	mitochondrial DNA metabolic process; mitochondrion organization; protein kinase B signaling; regulation of cAMP-dependent protein kinase activity; response to insulin; response to glucose; glucose homeostasis; glucose import; regulation of response to reactive oxygen species; triglyceride homeostasis; fatty acid beta-oxidation; negative regulation of TORC1 signaling; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; reactive oxygen species metabolic process; positive regulation of macroautophagy; cellular response to amino acid stimulus; regulation of protein phosphorylation; DNA damage response, signal transduction by p53 class mediator; cellular response to leucine; positive regulation of protein localization to nucleus; cellular oxidant detoxification; negative regulation of cell growth; cellular response to oxidative stress; negative regulation of translation in response to endoplasmic reticulum stress; positive regulation of lipophagy; cellular response to amino acid starvation; cellular response to glucose starvation; cellular response to leucine starvation; regulation of gluconeogenesis;
	Sources:Amigo / QuickGO
Orthologs
	83667
	230784
	ENSG00000130766; ENSG00000285069
	ENSMUSG00000028893
	P58004
	P58043
	NM_031459
	NM_144907
	NP_113647
	NP_659156
	Wikidata
View/Edit Human	View/Edit Mouse

Sestrin-2 also known as Hi95 is a protein that in humans is encoded by the SESN2 gene.