SETD3 (gene)

SETD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SMT
Identifiers
Aliases	SETD3, C14orf154, SET domain containing 3, SET domain containing 3, actin histidine methyltransferase, hSETD3
External IDs	OMIM: 615671; MGI: 1289184; HomoloGene: 41748; GeneCards: SETD3; OMA:SETD3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	99,480,889 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,145,573 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastrocnemius muscle; ; kidney tubule; ; muscle of thigh; ; beta cell; ; Skeletal muscle tissue of rectus abdominis; ; parotid gland; ; thoracic diaphragm; ; biceps brachii; ; corpus epididymis;
	Top expressed in
	muscle of thigh; ; quadriceps femoris muscle; ; superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; muscle tissue; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; Hypothalamus; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; histone methyltransferase activity (H3-K36 specific); transcription coactivator activity; protein-lysine N-methyltransferase activity;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of muscle cell differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; peptidyl-lysine methylation; methylation; positive regulation of transcription by RNA polymerase II; peptidyl-lysine dimethylation; peptidyl-lysine trimethylation; histone H3-K36 methylation; peptidyl-lysine monomethylation; histone H3-K4 methylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	84193
	52690
	ENSG00000183576
	ENSMUSG00000056770
	Q86TU7
	Q91WC0
	NM_032233; NM_199123
NM_028262; NM_001364266; NM_001364267; NM_001364268; NM_001364269;
	NM_001364270
	NP_115609; NP_954574
NP_082538; NP_001351195; NP_001351196; NP_001351197; NP_001351198;
	NP_001351199
	Wikidata
View/Edit Human	View/Edit Mouse

SET domain containing 3 (SETD3) is a protein that in humans is encoded by the SETD3 gene. It is a methyl transferase implicated in the replication of all enteroviruses. A mouse line deficient in SETD3 expression was shown to be immune to enterovirus infection. This could pave the way for the prevention of diseases like the common cold, myocarditis, aseptic meningitis and polio. SETD3 is capable of methylating the cytoskeletal protein actin on histidine residues.

In patients of the Estrogen Receptor-positive, and Luminal A-type breast cancer classification, a high expression of SETD3 is associated with better relapse-free survival, whereas in patients lacking expression of estrogen-, progesterone- and HER2/neu-receptor, and those affected by a p53-mutation, SETD3 was associated with poor relapse-free survival.

Downregulation of SETD3 expression with small interfering RNA resulted in an inhibition of cytoskeletal function and invasiveness of triple-negative breast cancer cells.