SETMAR

SETMAR
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3BO5, 3F2K, 3K9J, 3K9K
Identifiers
Aliases	SETMAR, HsMar1, METNASE, Mar1, SET domain and mariner transposase fusion gene
External IDs	OMIM: 609834; HomoloGene: 121979; GeneCards: SETMAR; OMA:SETMAR - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	4,317,265 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; popliteal artery; ; tibial arteries; ; left uterine tube; ; left ovary; ; right coronary artery; ; Descending thoracic aorta; ; gastric mucosa; ; right ovary; ; left coronary artery;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein homodimerization activity; zinc ion binding; histone methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; metal ion binding; single-stranded DNA binding; single-stranded DNA endodeoxyribonuclease activity; DNA topoisomerase binding; protein binding; catalytic activity; nuclease activity; endonuclease activity; histone methyltransferase activity (H3-K36 specific); double-stranded DNA binding; hydrolase activity; DNA binding;
Cellular component	site of double-strand break; chromosome; condensed chromosome; nucleus; nucleolus;
Biological process	histone H3-K36 dimethylation; DNA integration; nucleic acid phosphodiester bond hydrolysis; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; DNA double-strand break processing; positive regulation of double-strand break repair via nonhomologous end joining; DNA catabolic process, endonucleolytic; cellular response to DNA damage stimulus; histone H3-K36 methylation; histone H3-K4 methylation; methylation; replication fork processing; histone lysine methylation; mitotic DNA integrity checkpoint signaling; metabolism; cell population proliferation; double-strand break repair via nonhomologous end joining; negative regulation of chromosome organization; DNA repair; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	6419
	n/a
	ENSG00000170364
	n/a
	Q53H47
	n/a
NM_001243723; NM_001276325; NM_006515; NM_001320676; NM_001320677;
	NM_001320678
	n/a
NP_001230652; NP_001263254; NP_001307605; NP_001307606; NP_001307607;
	NP_006506
	n/a
	Wikidata
View/Edit Human

Histone-lysine N-methyltransferase SETMAR is an enzyme that in humans is encoded by the SETMAR gene.