SETX

SETX
Identifiers
Aliases	SETX, ALS4, AOA2, SCAR1, bA479K20.2, senataxin, Sen1, SCAN2, STEX
External IDs	OMIM: 608465; MGI: 2443480; HomoloGene: 41003; GeneCards: SETX; OMA:SETX - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	132,354,986 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,072,483 bp
RNA expression pattern
	Top expressed in
	right testis; ; Achilles tendon; ; left testis; ; white blood cell; ; monocyte; ; granulocyte; ; right lobe of thyroid gland; ; testicle; ; spleen; ; left lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; hand; ; superior cervical ganglion; ; mesenteric lymph nodes; ; Gonadal ridge; ; substantia nigra; ; condyle; ; foot;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription termination site sequence-specific DNA binding; nucleotide binding; protein binding; ATP binding; helicase activity; DNA helicase activity; identical protein binding; hydrolase activity; DNA binding; RNA binding;
Cellular component	nucleolus; telomere; nuclear chromosome; chromosome; cell projection; cytoplasm; growth cone; nucleoplasm; axon; nucleus; nuclear body; intercellular bridge;
Biological process	cellular response to fibroblast growth factor stimulus; positive regulation of DNA-templated transcription, termination; fibroblast growth factor receptor signaling pathway; positive regulation of RNA splicing; DNA recombination; cellular response to retinoic acid; nervous system development; positive regulation of neuron projection development; DNA repair; RNA processing; termination of RNA polymerase II transcription; cell differentiation; DNA-templated transcription, termination; mRNA splice site selection; cellular response to hydrogen peroxide; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled; negative regulation of apoptotic process; positive regulation of DNA-templated transcription, initiation; circadian rhythm; cellular response to oxidative stress; spermatogenesis; protein kinase B signaling; rhythmic process; positive regulation of transcription by RNA polymerase II; MAPK cascade; cellular response to DNA damage stimulus; DNA duplex unwinding; double-strand break repair;
	Sources:Amigo / QuickGO
Orthologs
	23064
	269254
	ENSG00000107290
	ENSMUSG00000043535
	Q7Z333
	A2AKX3
	NM_015046; NM_001351527; NM_001351528
	NM_198033; NM_177365
	NP_055861; NP_001338456; NP_001338457
	NP_932150
	Wikidata
View/Edit Human	View/Edit Mouse

Probable helicase senataxin is an enzyme that in humans is encoded by the SETX gene.

This gene encodes a protein named senataxin, a 302kDa protein