SF3A3

SF3A3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DT7
Identifiers
Aliases	SF3A3, PRP9, PRPF9, SAP61, SF3a60, splicing factor 3a subunit 3
External IDs	OMIM: 605596; MGI: 1922312; HomoloGene: 4949; GeneCards: SF3A3; OMA:SF3A3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,990,075 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,626,253 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; epithelium of colon; ; ganglionic eminence; ; ventricular zone; ; monocyte; ; rectum; ; gastrocnemius muscle; ; islet of Langerhans; ; stromal cell of endometrium;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; primitive streak; ; tail of embryo; ; abdominal wall; ; epiblast; ; embryo; ; primary oocyte; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; nucleic acid binding; RNA binding;
Cellular component	nuclear speck; catalytic step 2 spliceosome; spliceosomal complex; nucleus; nucleoplasm; U2 snRNP; U2-type precatalytic spliceosome;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; mRNA processing; mRNA 3'-splice site recognition; RNA splicing; U2-type prespliceosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	10946
	75062
	ENSG00000183431
	ENSMUSG00000028902
	Q12874
	Q9D554
	NM_006802; NM_001320830
	NM_029157
	NP_001307759; NP_006793
	NP_083433
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.