Stratifin

SFN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YWT, 1YZ5, 3IQJ, 3IQU, 3IQV, 3LW1, 3MHR, 3O8I, 3P1N, 3P1O, 3P1P, 3P1Q, 3P1R, 3P1S, 3SMK, 3SML, 3SMM, 3SMN, 3SMO, 3SPR, 3T0L, 3T0M, 3U9X, 3UX0, 4DAT, 4DAU, 4DHM, 4DHN, 4DHO, 4DHP, 4DHQ, 4DHR, 4DHS, 4DHT, 4DHU, 4FL5, 4FR3, 4HQW, 4HRU, 4IEA, 4JC3, 4JDD, 4QLI, 5HF3, 4Y5I, 4Y32, 4Y3B, 3SP5
Identifiers
Aliases	SFN, YWHAS, Stratifin
External IDs	OMIM: 601290; MGI: 1891831; HomoloGene: 4475; GeneCards: SFN; OMA:SFN - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,864,456 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,329,479 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; hair follicle; ; mucosa of pharynx; ; nipple; ; vulva; ; skin of thigh; ; human penis; ; skin of hip; ; oral cavity; ; body of tongue;
	Top expressed in
	lip; ; esophagus; ; blastocyst; ; morula; ; skin of abdomen; ; skin of external ear; ; transitional epithelium of urinary bladder; ; skin of back; ; intestinal villus; ; cervix;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; phosphoprotein binding; protein binding; protein kinase binding; protein kinase C inhibitor activity; identical protein binding; cadherin binding;
Cellular component	extracellular region; extracellular exosome; cytoplasmic vesicle membrane; nucleus; mitochondrion; extracellular space; cytoplasm; cytosol;
Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of keratinocyte proliferation; negative regulation of protein kinase activity; establishment of skin barrier; keratinization; keratinocyte differentiation; regulation of cell cycle; positive regulation of protein export from nucleus; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; keratinocyte development; positive regulation of cell growth; regulation of epidermal cell division; intrinsic apoptotic signaling pathway in response to DNA damage; membrane organization; positive regulation of epidermal cell differentiation; signal transduction; release of cytochrome c from mitochondria; skin development; negative regulation of protein serine/threonine kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	2810
	55948
	ENSG00000175793
	ENSMUSG00000047281
	P31947
	O70456
	NM_006142
	NM_018754
	NP_006133
	NP_061224
	Wikidata
View/Edit Human	View/Edit Mouse

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans. The protein is named for its presence in stratified epithelial cells.