SFPQ

SFPQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WII, 4WIJ, 4WIK
Identifiers
Aliases	SFPQ, POMP100, PPP1R140, PSF, splicing factor proline and glutamine rich
External IDs	OMIM: 605199; MGI: 1918764; HomoloGene: 3714; GeneCards: SFPQ; OMA:SFPQ - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	35,193,446 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	127,037,013 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; ventricular zone; ; ganglionic eminence; ; right uterine tube; ; sural nerve; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; left ovary; ; right ovary; ; sperm;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; mandibular prominence; ; Rostral migratory stream; ; maxillary prominence; ; epiblast; ; abdominal wall; ; ganglionic eminence; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; histone deacetylase binding; chromatin binding; transcription cis-regulatory region binding; protein binding; nucleic acid binding; DNA binding; protein homodimerization activity; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding;
Cellular component	cytoplasm; paraspeckles; nuclear matrix; RNA polymerase II transcription regulator complex; chromatin; nucleus; nucleoplasm; extracellular matrix; nuclear speck; dendrite cytoplasm;
Biological process	histone H3 deacetylation; DNA recombination; regulation of transcription, DNA-templated; rhythmic process; negative regulation of circadian rhythm; mRNA processing; negative regulation of transcription by RNA polymerase II; chromosome organization; transcription, DNA-templated; cellular response to DNA damage stimulus; regulation of cell cycle; regulation of circadian rhythm; double-strand break repair via homologous recombination; RNA splicing; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of sister chromatid cohesion; negative regulation of transcription, DNA-templated; alternative mRNA splicing, via spliceosome; DNA repair; positive regulation of transcription by RNA polymerase II; activation of innate immune response; immune system process; innate immune response; dendritic transport of messenger ribonucleoprotein complex;
	Sources:Amigo / QuickGO
Orthologs
	6421
	71514
	ENSG00000116560
	ENSMUSG00000028820
	P23246
	Q8VIJ6
	NM_005066
	NM_023603
	NP_005057
	NP_076092
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.