Secreted frizzled-related protein 1

SFRP1
Identifiers
Aliases	SFRP1, FRP, FRP-1, FRP1, FrzA, SARP2, secreted frizzled related protein 1
External IDs	OMIM: 604156; MGI: 892014; HomoloGene: 2266; GeneCards: SFRP1; OMA:SFRP1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	41,309,473 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,939,648 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; parotid gland; ; lactiferous duct; ; Epithelium of choroid plexus; ; ganglionic eminence; ; hair follicle; ; renal medulla; ; nipple; ; synovial joint; ; vena cava;
	Top expressed in
	epithelium of lens; ; efferent ductule; ; ventricular zone; ; Gonadal ridge; ; retinal pigment epithelium; ; ciliary body; ; corneal stroma; ; vas deferens; ; stroma of bone marrow; ; atrium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	frizzled binding; protein binding; cysteine-type endopeptidase activity; identical protein binding; heparin binding; Wnt-protein binding; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	extracellular region; extracellular exosome; cell surface; intracellular anatomical structure; extracellular matrix; plasma membrane; cytosol; extracellular space; integral component of membrane; collagen-containing extracellular matrix;
Biological process	positive regulation of smoothened signaling pathway; cellular response to fibroblast growth factor stimulus; development of primary male sexual characteristics; somatic stem cell population maintenance; Wnt signaling pathway involved in somitogenesis; negative regulation of JUN kinase activity; somitogenesis; negative regulation of androgen receptor signaling pathway; menstrual cycle phase; negative regulation of bone remodeling; digestive tract morphogenesis; negative regulation of fibroblast apoptotic process; negative regulation of fibroblast proliferation; hematopoietic progenitor cell differentiation; negative regulation of epithelial cell proliferation; positive regulation of cell-matrix adhesion; cellular response to X-ray; cellular response to starvation; bone trabecula formation; cellular response to estradiol stimulus; positive regulation of GTPase activity; positive regulation of Wnt signaling pathway; dopaminergic neuron differentiation; cellular response to interleukin-1; positive regulation of non-canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of stress fiber assembly; cellular response to hypoxia; regulation of branching involved in prostate gland morphogenesis; negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; response to organic cyclic compound; negative regulation of cell migration; negative regulation of transcription, DNA-templated; negative regulation of osteoblast differentiation; negative regulation of epithelial to mesenchymal transition; negative regulation of BMP signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of cell growth; regulation of cell cycle process; cellular response to vitamin D; hematopoietic stem cell differentiation; regulation of angiogenesis; male gonad development; dorsal/ventral axis specification; negative regulation of osteoclast differentiation; Wnt signaling pathway, planar cell polarity pathway; neural crest cell fate commitment; positive regulation of focal adhesion assembly; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of planar cell polarity pathway involved in axis elongation; hemopoiesis; ureteric bud development; cellular response to BMP stimulus; neural tube development; cell differentiation; negative regulation of insulin secretion; osteoblast differentiation; positive regulation of fat cell differentiation; cellular response to transforming growth factor beta stimulus; stromal-epithelial cell signaling involved in prostate gland development; Wnt signaling pathway; cellular response to heparin; positive regulation of apoptotic process; cellular response to growth factor stimulus; positive regulation of fibroblast apoptotic process; canonical Wnt signaling pathway; negative regulation of cell growth; positive regulation of transcription, DNA-templated; convergent extension involved in somitogenesis; multicellular organism development; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; planar cell polarity pathway involved in neural tube closure; negative regulation of osteoblast proliferation; anterior/posterior pattern specification; negative regulation of B cell differentiation; regulation of establishment of planar polarity; cellular response to tumor necrosis factor; female gonad development; negative regulation of cell population proliferation; negative regulation of apoptotic process; positive regulation of epithelial cell proliferation; neural tube closure; positive regulation of canonical Wnt signaling pathway; negative regulation of Wnt signaling pathway; negative regulation of ossification; negative regulation of gene expression; cellular response to estrogen stimulus; regulation of midbrain dopaminergic neuron differentiation; regulation of neuron projection development; cellular response to prostaglandin E stimulus; negative regulation of canonical Wnt signaling pathway; proteolysis; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6422
	20377
	ENSG00000104332
	ENSMUSG00000031548
	Q8N474
	Q8C4U3
	NM_003012
	NM_013834
	NP_003003
	NP_038862
	Wikidata
View/Edit Human	View/Edit Mouse

Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene.