SFRP5

SFRP5
Identifiers
Aliases	SFRP5, SARP3, secreted frizzled related protein 5
External IDs	OMIM: 604158; MGI: 1860298; HomoloGene: 2268; GeneCards: SFRP5; OMA:SFRP5 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,771,999 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	42,190,691 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; tibial nerve; ; body of pancreas; ; sural nerve; ; right auricle of heart; ; cardiac muscle tissue of right atrium; ; muscle layer of sigmoid colon; ; olfactory bulb; ; cartilage tissue; ; duodenum;
	Top expressed in
	sciatic nerve; ; decidua; ; gastrula; ; vestibular sensory epithelium; ; lumbar spinal ganglion; ; lacrimal gland; ; islet of Langerhans; ; parotid gland; ; retinal pigment epithelium; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; Wnt-protein binding; Wnt-activated receptor activity;
Cellular component	extracellular region; extracellular space; integral component of membrane;
Biological process	cell differentiation; negative regulation of protein kinase B signaling; negative regulation of Wnt signaling pathway; anatomical structure morphogenesis; Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; multicellular organism development; establishment or maintenance of cell polarity; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis; negative regulation of canonical Wnt signaling pathway; signal transduction; visual perception; negative regulation of cell population proliferation; apoptotic process; regulation of Wnt signaling pathway; regulation of BMP signaling pathway; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6425
	54612
	ENSG00000120057
	ENSMUSG00000018822
	Q5T4F7
	Q9WU66
	NM_003015
	NM_018780
	NP_003006
	NP_061250
	Wikidata
View/Edit Human	View/Edit Mouse

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.