Surfactant protein B

SFTPB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DFW, 1KMR, 1RG3, 1RG4, 1SSZ, 2DWF, 2JOU, 2M0H, 2M1T
Identifiers
Aliases	SFTPB, PSP-B, SFTB3, SFTP3, SMDP1, SP-B, surfactant protein B, Surfactant protein B
External IDs	OMIM: 178640; MGI: 109516; HomoloGene: 456; GeneCards: SFTPB; OMA:SFTPB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,668,741 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,291,354 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; upper lobe of lung; ; upper lobe of left lung; ; right lung; ; tendon of biceps brachii; ; sperm; ; buccal mucosa cell; ; right lobe of thyroid gland; ; mucosa of paranasal sinus;
	Top expressed in
	lung; ; pulmonary alveolar epithelium; ; alveolar duct; ; bronchiole; ; epithelium of bronchiole; ; granulocyte; ; morula; ; zygote; ; heart; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme activator activity; G protein-coupled receptor binding;
Cellular component	multivesicular body; extracellular region; clathrin-coated endocytic vesicle; lysosome; lamellar granule; endoplasmic reticulum membrane; alveolar lamellar body; multivesicular body lumen; nucleoplasm; extracellular space;
Biological process	animal organ morphogenesis; respiratory gaseous exchange by respiratory system; sphingolipid metabolic process; lipid metabolism; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	6439
	20388
	ENSG00000168878
	ENSMUSG00000056370
	P07988
	P50405
	NM_000542; NM_198843; NM_001367281
	NM_001282071; NM_147779
	NP_000533; NP_942140; NP_001354210
	NP_001269000; NP_680088
	Wikidata
View/Edit Human	View/Edit Mouse

Surfactant protein B is an essential lipid-associated protein found in pulmonary surfactant. Without it, the lung would not be able to inflate after a deep breath out. It rearranges lipid molecules in the fluid lining the lung so that tiny air sacs in the lung, called alveoli, can more easily inflate.