Surfactant protein D

SFTPD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR, 4E52, 4M17, 4M18
Identifiers
Aliases	SFTPD, COLEC7, PSP-D, SFTP4, SP-D, surfactant protein D
External IDs	OMIM: 178635; MGI: 109515; HomoloGene: 2272; GeneCards: SFTPD; OMA:SFTPD - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	79,982,614 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	40,907,106 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; upper lobe of lung; ; upper lobe of left lung; ; right lung; ; testicle; ; germinal epithelium; ; body of pancreas; ; skin of leg; ; left lobe of thyroid gland;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; left lung lobe; ; lacrimal gland; ; trachea; ; olfactory epithelium; ; parotid gland; ; uterus; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; carbohydrate binding; identical protein binding; lipopolysaccharide binding; monosaccharide binding;
Cellular component	cytoplasm; collagen; endoplasmic reticulum membrane; clathrin-coated endocytic vesicle; endocytic vesicle; extracellular region; lysosome; extracellular space; multivesicular body; rough endoplasmic reticulum;
Biological process	surfactant homeostasis; positive regulation of phagocytosis; immune system process; receptor-mediated endocytosis; respiratory gaseous exchange by respiratory system; reactive oxygen species metabolic process; regulation of cytokine production; negative regulation of T cell proliferation; macrophage chemotaxis; defense response to bacterium; regulation of immune response; lung alveolus development; innate immune response; toll-like receptor signaling pathway; induction of bacterial agglutination; regulation of adhesion of symbiont to host epithelial cell; developmental process;
	Sources:Amigo / QuickGO
Orthologs
	6441
	20390
	ENSG00000133661
	ENSMUSG00000021795
	P35247
	P50404
	NM_003019
	NM_009160
	NP_003010
	NP_033186
	Wikidata
View/Edit Human	View/Edit Mouse

Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin. In humans, SP-D is encoded by the SFTPD gene and is part of the innate immune system. Each SP-D subunit is composed of an N-terminal domain, a collagenous region, a nucleating neck region, and a C-terminal lectin domain. Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.