SGK1

SGK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R5T, 3HDM, 3HDN
Identifiers
Aliases	SGK1, SGK, serum/glucocorticoid regulated kinase 1
External IDs	OMIM: 602958; MGI: 1340062; HomoloGene: 48364; GeneCards: SGK1; OMA:SGK1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	134,318,112 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	21,875,802 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; right lung; ; Epithelium of choroid plexus; ; gingival epithelium; ; parietal pleura; ; mucosa of urinary bladder; ; nasal epithelium; ; lower lobe of lung; ; gallbladder; ; retinal pigment epithelium;
	Top expressed in
	seminal vesicula; ; decidua; ; Epithelium of choroid plexus; ; gastrula; ; retinal pigment epithelium; ; iris; ; endothelial cell of lymphatic vessel; ; ciliary body; ; stria vascularis; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; sodium channel regulator activity; calcium channel regulator activity; kinase activity; potassium channel regulator activity; protein binding; protein serine/threonine/tyrosine kinase activity; chloride channel regulator activity; ATP binding; protein serine/threonine kinase activity;
Cellular component	endoplasmic reticulum membrane; membrane; plasma membrane; endoplasmic reticulum; mitochondrion; nucleus; cytoplasm; cytosol; nuclear speck;
Biological process	regulation of apoptotic process; intracellular signal transduction; regulation of cell migration; positive regulation of transporter activity; phosphorylation; sodium ion transport; cellular response to DNA damage stimulus; regulation of blood pressure; protein phosphorylation; ion transmembrane transport; regulation of cell population proliferation; regulation of DNA-binding transcription factor activity; regulation of cell growth; regulation of catalytic activity; renal sodium ion absorption; regulation of gastric acid secretion; apoptotic process; peptidyl-serine phosphorylation; long-term memory; neuron projection morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6446
	20393
	ENSG00000118515
	ENSMUSG00000019970
	O00141
	Q9WVC6
	NM_001143676; NM_001143677; NM_001143678; NM_001291995; NM_005627
NM_001161845; NM_001161847; NM_001161848; NM_001161849; NM_001161850;
	NM_011361
	NP_001137148; NP_001137149; NP_001137150; NP_001278924; NP_005618
NP_001155317; NP_001155319; NP_001155320; NP_001155321; NP_001155322;
	NP_035491
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.

SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids. The kinase is activated by insulin and growth factors via phosphatidylinositide-3-kinase, phosphoinositide-dependent protein kinase PDPK1 and mammalian target of rapamycin mTORC2. It has been shown to "regulate several enzymes and transcription factors; SGK1 contributes to the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation and apoptosis". SGK1 increases the protein abundance and/or activity of a variety of ion channel, carriers, and the Na+/K+-ATPase. Over the past few years, there has been increasing evidence that SGK1 expression is regulated during both discrete developmental stages and pathological conditions such as hypertension, diabetic neuropathy, ischemia, trauma, and neurodegenerative diseases.