SH2B3

SH2B3
Identifiers
Aliases	SH2B3, IDDM20, LNK, SH2B adaptor protein 3
External IDs	OMIM: 605093; MGI: 893598; HomoloGene: 36179; GeneCards: SH2B3; OMA:SH2B3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	111,451,623 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,975,709 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; right ventricle; ; myocardium of left ventricle; ; spleen; ; secondary oocyte; ; blood; ; lower lobe of lung; ; apex of heart; ; appendix;
	Top expressed in
	granulocyte; ; spleen; ; blood; ; mesenteric lymph nodes; ; stroma of bone marrow; ; hand; ; left lung lobe; ; external carotid artery; ; seminiferous tubule; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity; stem cell factor receptor binding; protein tyrosine kinase binding;
Cellular component	cytosol; plasma membrane;
Biological process	cell differentiation; positive regulation of signal transduction; intracellular signal transduction; blood coagulation; embryonic hemopoiesis; signal transduction; hemopoiesis; transmembrane receptor protein tyrosine kinase signaling pathway; neutrophil homeostasis; negative regulation of cell population proliferation; monocyte homeostasis; megakaryocyte development; cellular response to interleukin-3; thrombopoietin-mediated signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; negative regulation of MAP kinase activity; negative regulation of receptor signaling pathway via JAK-STAT; erythrocyte development; negative regulation of protein kinase B signaling; negative regulation of response to cytokine stimulus; negative regulation of chemokine-mediated signaling pathway; negative regulation of platelet aggregation; negative regulation of Kit signaling pathway; cellular response to chemokine;
	Sources:Amigo / QuickGO
Orthologs
	10019
	16923
	ENSG00000111252
	ENSMUSG00000042594
	Q9UQQ2
	O09039
	NM_001291424; NM_005475
	NM_008507; NM_001306126; NM_001306127; NM_001306128
	NP_001278353; NP_005466
	NP_001293055; NP_001293056; NP_001293057; NP_032533
	Wikidata
View/Edit Human	View/Edit Mouse

SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. SH2B3 is ubiquitously expressed in many tissues and cell types. LNK functions as a regulator in signaling pathways relating to hematopoiesis, inflammation, and cell migration. As a result, it is involved in blood diseases, autoimmune disorders, and vascular disease. The SH2B3 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.