SH2D1B

SH2D1B
Identifiers
Aliases	SH2D1B, EAT2, SH2 domain containing 1B
External IDs	OMIM: 608510; MGI: 1349420; HomoloGene: 8070; GeneCards: SH2D1B; OMA:SH2D1B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,412,138 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,114,338 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; gastrocnemius muscle; ; blood; ; testicle; ; sperm; ; muscle of thigh; ; monocyte; ; amniotic fluid; ; deltoid muscle; ; spleen;
	Top expressed in
	spleen; ; granulocyte; ; lung; ; jejunum; ; bone marrow; ; ileum; ; choroid plexus; ; prefrontal cortex; ; Medulla Oblongata; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding;
Cellular component	cytosol; intracellular anatomical structure;
Biological process	innate immune response; leukocyte activation involved in immune response; adaptive immune response; positive regulation of natural killer cell mediated immunity; positive regulation of innate immune response; regulation of immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	117157
	26904
	ENSG00000198574
	ENSMUSG00000102418
	O14796
	O35324; Q149T1
	NM_053282
	NM_012009
	NP_444512
	NP_036139
	Wikidata
View/Edit Human	View/Edit Mouse

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM]