SH2 domain
Crystallographic structure of the SH2 domain. The structure consists of a large beta sheet (green) flanked by two alpha-helices (orange and blue). | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | SH2 | ||||||||
| Pfam | PF00017 | ||||||||
| InterPro | IPR000980 | ||||||||
| SMART | SH2 | ||||||||
| PROSITE | PDOC50001 | ||||||||
| SCOP2 | 1sha / SCOPe / SUPFAM | ||||||||
| CDD | cd00173 | ||||||||
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The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains bind to phosphorylated tyrosine residues on other proteins, modifying the function or activity of the SH2-containing protein. The SH2 domain may be considered the prototypical modular protein-protein interaction domain, allowing the transmission of signals controlling a variety of cellular functions. SH2 domains are especially common in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.