SH3BP4

SH3BP4
Identifiers
Aliases	SH3BP4, BOG25, TTP, SH3 domain binding protein 4
External IDs	OMIM: 605611; MGI: 2138297; HomoloGene: 8726; GeneCards: SH3BP4; OMA:SH3BP4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	235,055,714 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	89,082,790 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; trachea; ; mucosa of paranasal sinus; ; renal medulla; ; germinal epithelium; ; nasal epithelium; ; caput epididymis; ; Epithelium of choroid plexus; ; tibia; ; epithelium of lactiferous gland;
	Top expressed in
	lacrimal gland; ; molar; ; parotid gland; ; maxillary prominence; ; seminal vesicula; ; mandibular prominence; ; ascending aorta; ; vestibular membrane of cochlear duct; ; somite; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; GDP-dissociation inhibitor activity;
Cellular component	cytoplasm; membrane; clathrin-coated pit; cytoplasmic vesicle; extracellular exosome; nucleus; clathrin-coated vesicle;
Biological process	cellular response to amino acid stimulus; protein localization to lysosome; negative regulation of GTPase activity; regulation of catalytic activity; endocytosis; negative regulation of cell growth; positive regulation of autophagy; amino acid import; negative regulation of cell population proliferation; negative regulation of TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
	23677
	98402
	ENSG00000130147
	ENSMUSG00000036206
	Q9P0V3
	Q921I6
	NM_014521
	NM_133816
NP_055336; NP_001358231; NP_001358232; NP_001358233; NP_001358234;
	NP_001358235
	NP_598577
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.