SH3GLB1

SH3GLB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X43
Identifiers
Aliases	SH3GLB1, Bif-1, PPP1R70, dJ612B15.2, CGI-61, SH3 domain containing GRB2 like endophilin B1, SH3 domain containing GRB2 like, endophilin B1
External IDs	OMIM: 609287; MGI: 1859730; HomoloGene: 9337; GeneCards: SH3GLB1; OMA:SH3GLB1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	86,748,184 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,426,096 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; right ventricle; ; muscle of trunk; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; thoracic diaphragm; ; oocyte; ; muscle of arm; ; biceps brachii;
	Top expressed in
	blood; ; seminiferous tubule; ; ankle; ; endothelial cell of lymphatic vessel; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; medial head of gastrocnemius muscle; ; right ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; identical protein binding; lipid binding; cadherin binding;
Cellular component	cytoplasm; Golgi apparatus; membrane; Golgi membrane; mitochondrial outer membrane; autophagosome membrane; midbody; mitochondrion; extracellular exosome; cytoplasmic vesicle; cytosol;
Biological process	cellular response to glucose starvation; regulation of cytokinesis; regulation of protein stability; positive regulation of autophagosome assembly; positive regulation of autophagy; positive regulation of protein targeting to mitochondrion; cellular response to amino acid starvation; receptor catabolic process; autophagy; protein complex oligomerization; membrane fission; positive regulation of protein oligomerization; positive regulation of membrane tubulation; autophagic cell death; regulation of macroautophagy; protein localization to vacuolar membrane; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	51100
	54673
	ENSG00000097033
	ENSMUSG00000037062
	Q9Y371
	Q9JK48
	NM_001206651; NM_001206652; NM_001206653; NM_016009
NM_001282037; NM_001282042; NM_019464; NM_001379170; NM_001379171;
	NM_001379172; NM_001379173; NM_001379174
	NP_001193580; NP_001193581; NP_001193582; NP_057093
NP_001268966; NP_001268971; NP_062337; NP_001366099; NP_001366100;
	NP_001366101; NP_001366102; NP_001366103
	Wikidata
View/Edit Human	View/Edit Mouse

Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene. Endophilin-B1 belongs to the Bin/Amphiphysin/Rvs167 (BAR) family of proteins and plays a critical role in mitochondrial fission and fusion, as well as in autophagy and apoptosis. Loss of functional endophilin-B1 is seen in many different forms of cancer. The link between carcinogenesis and dysregulation of cell death pathways suggests that endophilin-B1 serves a critical tumor suppressor role in the cell, although the underlying mechanisms are not known.