SHANK2

SHANK2
Identifiers
Aliases	SHANK2, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SH3 and multiple ankyrin repeat domains 2
External IDs	OMIM: 603290; MGI: 2671987; HomoloGene: 105965; GeneCards: SHANK2; OMA:SHANK2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	71,252,577 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,978,231 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; bronchial epithelial cell; ; middle temporal gyrus; ; Region I of hippocampus proper; ; entorhinal cortex; ; corpus epididymis; ; Epithelium of choroid plexus; ; endothelial cell; ; retinal pigment epithelium; ; primary visual cortex;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; otolith organ; ; utricle; ; cerebellar cortex; ; lobe of cerebellum; ; zygote; ; substantia nigra; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; synaptic receptor adaptor activity; ionotropic glutamate receptor binding; signaling receptor complex adaptor activity;
Cellular component	cytoplasm; postsynaptic membrane; cell projection; membrane; postsynaptic density; neurofilament; photoreceptor inner segment; growth cone; plasma membrane; dendritic spine; photoreceptor outer segment; synapse; brush border membrane; cell junction; soma; apical plasma membrane; ciliary membrane; neuron projection; ionotropic glutamate receptor complex; cytosol; cellular component; dendrite; neuron spine;
Biological process	learning; vocalization behavior; adult behavior; long-term depression; social behavior; synapse assembly; long-term potentiation; brain morphogenesis; synaptic assembly at neuromuscular junction; positive regulation of synaptic transmission, glutamatergic; dendritic spine morphogenesis; positive regulation of dendritic spine development; postsynaptic density assembly; regulation of AMPA receptor activity; positive regulation of excitatory postsynaptic potential;
	Sources:Amigo / QuickGO
Orthologs
	22941
	210274
	ENSG00000162105
	ENSMUSG00000037541
	Q9UPX8
	Q80Z38
	NM_012309; NM_133266; NM_001379226
	NM_001081370; NM_001113373
	NP_036441; NP_573573; NP_001366155
	NP_001074839; NP_001106844
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.