SHOC2

SHOC2
Identifiers
Aliases	SHOC2, SIAA0862, SOC2, SUR8, SHOC2 leucine-rich repeat scaffold protein, leucine rich repeat scaffold protein, SHOC2 leucine rich repeat scaffold protein, NSLH1
External IDs	OMIM: 602775; MGI: 1927197; HomoloGene: 7219; GeneCards: SHOC2; OMA:SHOC2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	111,017,307 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	54,021,564 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; bone marrow; ; epithelium of colon; ; bone marrow cells; ; tail of epididymis; ; testicle; ; corpus epididymis; ; jejunal mucosa; ; caput epididymis;
	Top expressed in
	genital tubercle; ; ascending aorta; ; aortic valve; ; pineal gland; ; tail of embryo; ; superior cervical ganglion; ; dorsomedial hypothalamic nucleus; ; pyloric antrum; ; renal corpuscle; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 1 binding; protein phosphatase regulator activity; protein phosphatase binding; protein binding; protein serine/threonine phosphatase activity;
Cellular component	protein phosphatase type 1 complex; nucleoplasm; nucleus; cytoplasm; cytosol; plasma membrane; photoreceptor inner segment; photoreceptor outer segment membrane;
Biological process	fibroblast growth factor receptor signaling pathway; positive regulation of Ras protein signal transduction; Ras protein signal transduction; regulation of phosphoprotein phosphatase activity; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8036
	56392
	ENSG00000108061
	ENSMUSG00000024976
	Q9UQ13
	O88520
	NM_001269039; NM_007373; NM_001324336; NM_001324337
	NM_001168505; NM_019658; NM_001355242
	NP_001255968; NP_001311265; NP_001311266; NP_031399
	NP_001161977; NP_062632; NP_001342171
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of SHOC2 is in modulating signals of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway by forming a holophosphatase complex that activates RAF proteins(PMID 16630891, 33526449). This protein was initially identified in Caenorhabditis elegans as SUR-8/SOC2 and was found to be a critical positive regulator of the ERK1/2 signaling pathway that integrates the Ras and RAF components of the ERK1/2 pathway into a multiprotein complex. Specifically, SHOC2 tethers RAS and PP1C proteins and in close proximity to RAF to dephosphorylate “S259” to enable MAPK signaling. It has been shown that activity that results in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.