SHOX2

SHOX2
Identifiers
Aliases	SHOX2, OG12, OG12X, SHOT, short stature homeobox 2
External IDs	OMIM: 602504; MGI: 1201673; HomoloGene: 68535; GeneCards: SHOX2; OMA:SHOX2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	158,106,420 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	66,889,104 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; lateral nuclear group of thalamus; ; saphenous vein; ; tendon of biceps brachii; ; sperm; ; popliteal artery; ; tibial arteries; ; Achilles tendon; ; spinal ganglia; ; tibial nerve;
	Top expressed in
	medial dorsal nucleus; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; inferior colliculi; ; lumbar spinal ganglion; ; electrical conduction system of the heart; ; body of femur; ; superior colliculus; ; dermis; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	cartilage development involved in endochondral bone morphogenesis; skeletal system development; regulation of chondrocyte differentiation; heart valve development; regulation of transcription, DNA-templated; chondrocyte differentiation; positive regulation of smoothened signaling pathway; chondrocyte development; negative regulation of transcription by RNA polymerase II; positive regulation of skeletal muscle fiber development; positive regulation of axonogenesis; nervous system development; multicellular organism development; heart development; positive regulation of mesenchymal cell proliferation; embryonic limb morphogenesis; muscle tissue morphogenesis; regulation of branching morphogenesis of a nerve; embryonic morphogenesis; osteoblast differentiation; embryonic digestive tract morphogenesis; embryonic skeletal joint morphogenesis; cardiac atrium morphogenesis; embryonic forelimb morphogenesis; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6474
	20429
	ENSG00000168779
	ENSMUSG00000027833
	O60902
	P70390
	NM_001163678; NM_003030; NM_006884
	NM_013665; NM_001302357; NM_001302358; NM_001302359
	NP_001157150; NP_003021; NP_006875
	NP_001289286; NP_001289287; NP_001289288; NP_038693
	Wikidata
View/Edit Human	View/Edit Mouse

Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.