SIGIRR

SIGIRR
Identifiers
Aliases	SIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDs	OMIM: 605478; MGI: 1344402; HomoloGene: 36399; GeneCards: SIGIRR; OMA:SIGIRR - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	417,455 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,680,485 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; right lobe of liver; ; right uterine tube; ; apex of heart; ; olfactory zone of nasal mucosa; ; spleen; ; body of stomach; ; C1 segment; ; left uterine tube;
	Top expressed in
	yolk sac; ; right kidney; ; proximal tubule; ; human kidney; ; epithelium of small intestine; ; thymus; ; intestinal villus; ; crypt of lieberkuhn of small intestine; ; ileum; ; submandibular gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	negative regulation of cytokine-mediated signaling pathway; acute-phase response; negative regulation of DNA-binding transcription factor activity; signal transduction; negative regulation of lipopolysaccharide-mediated signaling pathway; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	59307
	24058
	ENSG00000185187
	ENSMUSG00000025494
	Q6IA17
	Q9JLZ8
	NM_001135053; NM_001135054; NM_021805
	NM_023059; NM_001355055
	NP_001128525; NP_001128526; NP_068577
	NP_075546; NP_001341984
	Wikidata
View/Edit Human	View/Edit Mouse

Single Ig IL-1-related receptor (SIGIRR), also called Toll/Interleukin-1 receptor 8 (TIR8) or Interleukin-1 receptor 8 (IL-1R8), is transmembrane protein encoded by gene SIGIRR, which modulate inflammation, immune response, and tumorigenesis of colonic epithelial cells.