PMEL (gene)

PMEL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TVB, 1TVH, 3CC5, 4IS6, 5EU6, 5EU4, 5EU3
Identifiers
Aliases	PMEL, D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100, premelanosome protein, HMB-45, HMB45
External IDs	OMIM: 155550; MGI: 98301; HomoloGene: 5048; GeneCards: PMEL; OMA:PMEL - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	55,973,317 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,556,107 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; skin of thigh; ; vulva; ; skin of abdomen; ; testicle; ; ectocervix; ; human penis; ; skin of arm; ; nipple; ; gonad;
	Top expressed in
	iris; ; hair follicle; ; ciliary body; ; epithelium of lens; ; utricle; ; conjunctival fornix; ; spermatid; ; cornea; ; retinal pigment epithelium; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	multivesicular body; membrane; extracellular region; multivesicular body membrane; integral component of membrane; endosome; plasma membrane; endoplasmic reticulum; melanosome; Golgi apparatus; endoplasmic reticulum membrane; integral component of plasma membrane;
Biological process	melanin biosynthetic process; melanosome organization; developmental pigmentation;
	Sources:Amigo / QuickGO
Orthologs
	6490
	20431
	ENSG00000185664
	ENSMUSG00000025359
	P40967
	Q60696; Q9CZB2
NM_001200053; NM_001200054; NM_006928; NM_001320121; NM_001320122;
	NM_001384361
	NM_021882
	NP_001186982; NP_001186983; NP_001307050; NP_001307051; NP_008859
	NP_068682
	Wikidata
View/Edit Human	View/Edit Mouse

Melanocyte protein PMEL also known as premelanosome protein (PMEL), silver locus protein homolog (SILV) or Glycoprotein 100 (gp100), is a protein that in humans is encoded by the PMEL gene. Its gene product may be referred to as PMEL, silver, ME20, gp100 or Pmel17.