SIM2

SIM2
Identifiers
Aliases	SIM2, HMC13F06, HMC29C01, SIM, bHLHe15, single-minded family bHLH transcription factor 2, SIM bHLH transcription factor 2
External IDs	OMIM: 600892; MGI: 98307; HomoloGene: 3716; GeneCards: SIM2; OMA:SIM2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,749,917 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; buccal mucosa cell; ; oral cavity; ; amniotic fluid; ; vastus lateralis muscle; ; human kidney; ; superior surface of tongue; ; tibia; ; testicle; ; nipple;
	Top expressed in
	esophagus; ; trachea; ; soleus muscle; ; submandibular gland; ; triceps brachii muscle; ; molar; ; vastus lateralis muscle; ; knee joint; ; gastrocnemius muscle; ; main bronchus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein heterodimerization activity; protein dimerization activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nuclear body; nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; cell differentiation; embryonic pattern specification; transcription, DNA-templated; lung development; negative regulation of transcription, DNA-templated; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	6493
	20465
	ENSG00000159263
	ENSMUSG00000062713
	Q14190
	n/a
	NM_005069; NM_009586
	NM_011377
	NP_005060; NP_033664
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Single-minded homolog 2 is a protein that in humans is encoded by the SIM2 gene. It plays a major role in the development of the central nervous system midline as well as the construction of the face and head.