SIPA1

SIPA1
Identifiers
Aliases	SIPA1, SPA1, signal-induced proliferation-associated 1
External IDs	OMIM: 602180; MGI: 107576; HomoloGene: 7940; GeneCards: SIPA1; OMA:SIPA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,650,918 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,713,735 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; apex of heart; ; upper lobe of left lung; ; sural nerve; ; right lung; ; monocyte; ; blood; ; right lobe of liver; ; left uterine tube;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; yolk sac; ; spleen; ; thymus; ; blood; ; internal carotid artery; ; external carotid artery; ; tibiofemoral joint; ; left lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; GTPase activator activity; protein C-terminus binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; cytosol; transport vesicle; membrane; endomembrane system; nucleus; protein-containing complex;
Biological process	negative regulation of cell adhesion; negative regulation of cell cycle; cellular response to water deprivation; cell population proliferation; intracellular signal transduction; regulation of small GTPase mediated signal transduction; cytoskeleton organization; negative regulation of cell growth; signal transduction; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	6494
	20469
	ENSG00000213445
	ENSMUSG00000056917
	Q96FS4
	P46062
	NM_006747; NM_153253
	NM_001164480; NM_001164481; NM_001164482; NM_001164568; NM_011379
	NP_006738; NP_694985
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.