Sirtuin 2

SIRT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J8F, 3ZGO, 3ZGV, 4L3O, 4R8M, 4RMG, 4RMH, 4RMI, 4RMJ, 4Y6O, 5DY4, 5D7O, 5DY5, 4Y6L, 4Y6Q, 4X3O, 4X3P, 5D7P, 5D7Q, 5FYQ
Identifiers
Aliases	SIRT2, SIR2, SIR2L, SIR2L2, sirtuin 2
External IDs	OMIM: 604480; MGI: 1927664; HomoloGene: 40823; GeneCards: SIRT2; OMA:SIRT2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,899,862 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,488,086 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; muscle of thigh; ; gastrocnemius muscle; ; right frontal lobe; ; Brodmann area 9; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; Hypothalamus; ; Amygdala; ; tibial nerve;
	Top expressed in
	optic nerve; ; deep cerebellar nuclei; ; globus pallidus; ; median eminence; ; pontine nuclei; ; genital tubercle; ; internal carotid artery; ; lateral geniculate nucleus; ; dorsal tegmental nucleus; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding; transcription factor binding; metal ion binding; protein deacetylase activity; zinc ion binding; chromatin binding; protein binding; histone acetyltransferase binding; tubulin deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); NAD-dependent protein deacetylase activity; histone deacetylase activity; ubiquitin binding; NAD+ binding; beta-tubulin binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; NAD-dependent histone deacetylase activity;
Cellular component	cytoplasm; cytosol; membrane; microtubule organizing center; chromatin silencing complex; perinuclear region of cytoplasm; paranode region of axon; microtubule; cytoskeleton; nucleus; centrosome; cell projection; myelin sheath; glial cell projection; Schmidt-Lanterman incisure; paranodal junction; perikaryon; growth cone; spindle; chromosome; lateral loop; mitotic spindle; meiotic spindle; midbody; centriole; juxtaparanode region of axon; telomere; nucleolus; mitochondrion; plasma membrane;
Biological process	cellular response to molecule of bacterial origin; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; cellular response to epinephrine stimulus; tubulin deacetylation; rDNA heterochromatin assembly; phosphatidylinositol 3-kinase signaling; cell cycle; positive regulation of DNA binding; negative regulation of autophagy; cellular response to hypoxia; negative regulation of cell population proliferation; proteasome-mediated ubiquitin-dependent protein catabolic process; cellular lipid catabolic process; histone H3 deacetylation; peptidyl-lysine deacetylation; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; substantia nigra development; negative regulation of protein catabolic process; negative regulation of NLRP3 inflammasome complex assembly; negative regulation of oligodendrocyte progenitor proliferation; regulation of fat cell differentiation; transcription, DNA-templated; myelination in peripheral nervous system; histone H4 deacetylation; regulation of myelination; innate immune response; hepatocyte growth factor receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of exit from mitosis; cell differentiation; protein ADP-ribosylation; immune system process; cellular response to hepatocyte growth factor stimulus; negative regulation of peptidyl-threonine phosphorylation; regulation of phosphorylation; negative regulation of transcription by RNA polymerase II; nervous system development; response to redox state; protein deacetylation; positive regulation of attachment of spindle microtubules to kinetochore; meiosis; cellular response to caloric restriction; ripoptosome assembly involved in necroptotic process; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of transcription, DNA-templated; negative regulation of defense response to bacterium; positive regulation of execution phase of apoptosis; protein kinase B signaling; negative regulation of striated muscle tissue development; positive regulation of oocyte maturation; regulation of cell cycle; cell division; autophagy; positive regulation of meiotic nuclear division; cellular response to oxidative stress; negative regulation of reactive oxygen species metabolic process; histone deacetylation; positive regulation of cell division; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	22933
	64383
	ENSG00000283100; ENSG00000068903
	ENSMUSG00000015149
	Q8IXJ6
	Q8VDQ8
	NM_001193286; NM_012237; NM_030593
	NM_001122765; NM_001122766; NM_022432
	NP_001180215; NP_036369; NP_085096
	NP_001116237; NP_001116238; NP_071877
	Wikidata
View/Edit Human	View/Edit Mouse

NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context. The natural polyphenol resveratrol is known to exert opposite actions on neural cells according to their normal or cancerous status. Similar to other sirtuin family members, SIRT2 displays a ubiquitous distribution. SIRT2 is expressed in a wide range of tissues and organs and has been detected particularly in metabolically relevant tissues, including the brain, muscle, liver, testes, pancreas, kidney, and adipose tissue of mice. Of note, SIRT2 expression is much higher in the brain than all other organs studied, particularly in the cortex, striatum, hippocampus, and spinal cord.