Sirtuin 3

SIRT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GLR, 3GLS, 3GLU, 4BN4, 4BN5, 4BV3, 4BVB, 4BVE, 4BVF, 4BVG, 4BVH, 4C78, 4C7B, 4FVT, 4FZ3, 4HD8, 4JSR, 4JT8, 4JT9, 4O8Z, 4V1C, 5D7N, 5BWN, 5BWO
Identifiers
Aliases	SIRT3, SIR2L3, sirtuin 3
External IDs	OMIM: 604481; MGI: 1927665; HomoloGene: 81827; GeneCards: SIRT3; OMA:SIRT3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	236,931 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,462,222 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; apex of heart; ; left testis; ; right testis; ; right uterine tube; ; right lobe of liver; ; nucleus accumbens; ; caudate nucleus; ; anterior pituitary; ; Brodmann area 9;
	Top expressed in
	proximal tubule; ; right kidney; ; left lobe of liver; ; facial motor nucleus; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; substantia nigra; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; human kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	NAD+ ADP-ribosyltransferase activity; protein binding; hydrolase activity; NAD+ binding; metal ion binding; zinc ion binding; NAD-dependent histone deacetylase activity; NAD-dependent protein deacetylase activity; sequence-specific DNA binding; enzyme binding;
Cellular component	mitochondrion; mitochondrial matrix; protein-containing complex; cytoplasm; nucleoplasm;
Biological process	protein deacetylation; aerobic respiration; mitochondrion organization; peptidyl-lysine deacetylation; protein ADP-ribosylation; negative regulation of ERK1 and ERK2 cascade; positive regulation of insulin secretion; negative regulation of reactive oxygen species metabolic process; ageing; histone deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	23410
	64384
	ENSG00000142082
	ENSMUSG00000025486
	Q9NTG7
	Q8R104
	NM_001017524; NM_012239
	NM_001127351; NM_001177804; NM_022433
NP_001017524; NP_036371; NP_001357239; NP_001357241; NP_001357243;
	NP_001357244; NP_001357245; NP_001357246; NP_001357247; NP_001357248; NP_001357249; NP_001357250; NP_001357251; NP_001357252; NP_001357253; NP_001357254
	NP_001120823; NP_001171275; NP_071878
	Wikidata
View/Edit Human	View/Edit Mouse

NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT3 exhibits NAD+-dependent deacetylase activity.

Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes, and the protein encoded by this gene is included in class I of the sirtuin family. The human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance, and metabolic regulation. Yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. In addition to protein deacetylation, studies have shown that the human sirtuins may also function as intracellular regulatory proteins with mono ADP ribosyltransferase activity.