Sirtuin 4

SIRT4
Identifiers
Aliases	SIRT4, SIR2L4, sirtuin 4
External IDs	OMIM: 604482; MGI: 1922637; HomoloGene: 8164; GeneCards: SIRT4; OMA:SIRT4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,313,249 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,484,725 bp
RNA expression pattern
	Top expressed in
	testicle; ; apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; right adrenal gland; ; sperm; ; left ventricle; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	neural layer of retina; ; primary visual cortex; ; superior frontal gyrus; ; right kidney; ; lip; ; spermatid; ; zygote; ; muscle of thigh; ; ventricular zone; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; NAD-dependent protein deacetylase activity; metal ion binding; protein binding; NAD+ binding; lipoamidase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity; biotinidase activity; zinc ion binding;
Cellular component	mitochondrion; mitochondrial inner membrane; mitochondrial matrix;
Biological process	peptidyl-lysine deacetylation; negative regulation of insulin secretion; positive regulation of lipid biosynthetic process; protein ADP-ribosylation; regulation of glutamine family amino acid metabolic process; negative regulation of fatty acid oxidation; regulation of pyruvate dehydrogenase activity; cellular response to DNA damage stimulus; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of cardiac muscle cell apoptotic process; glutamine metabolic process; tricarboxylic acid metabolic process; cellular response to hypoxia; mitochondrion organization; protein deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	23409
	75387
	ENSG00000089163
	ENSMUSG00000029524
	Q9Y6E7
	Q8R216
	NM_012240; NM_001385733; NM_001385734; NM_001385735
	NM_001167691; NM_133760
	NP_036372
	NP_001161163; NP_598521
	Wikidata
View/Edit Human	View/Edit Mouse

Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT4 exhibits NAD+-dependent deacetylase activity.