Sirtuin 5

SIRT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B4Y, 2NYR, 3RIG, 3RIY, 4F4U, 4F56, 4G1C, 4HDA, 5BWL
Identifiers
Aliases	SIRT5, SIR2L5, sirtuin 5
External IDs	OMIM: 604483; MGI: 1915596; HomoloGene: 40825; GeneCards: SIRT5; OMA:SIRT5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	13,615,158 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	43,548,679 bp
RNA expression pattern
	Top expressed in
	thoracic diaphragm; ; apex of heart; ; left ventricle; ; buccal mucosa cell; ; Skeletal muscle tissue of rectus abdominis; ; right lobe of liver; ; body of tongue; ; muscle of thigh; ; tendon of biceps brachii; ; biceps brachii;
	Top expressed in
	interventricular septum; ; morula; ; extraocular muscle; ; myocardium of ventricle; ; left lobe of liver; ; soleus muscle; ; hand; ; digastric muscle; ; tibialis anterior muscle; ; quadriceps femoris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; metal ion binding; NAD+ ADP-ribosyltransferase activity; NAD+ binding; protein-succinyllysine desuccinylase activity; protein-malonyllysine demalonylase activity; zinc ion binding; NAD-dependent protein deacetylase activity; protein-glutaryllysine deglutarylase activity;
Cellular component	cytoplasm; mitochondrial intermembrane space; mitochondrion; nucleus; cytosol; mitochondrial matrix; mitochondrial inner membrane;
Biological process	protein deacetylation; negative regulation of cardiac muscle cell apoptotic process; response to nutrient levels; protein ADP-ribosylation; negative regulation of reactive oxygen species metabolic process; peptidyl-lysine deglutarylation; mitochondrion organization; regulation of ketone biosynthetic process; protein demalonylation; peptidyl-lysine demalonylation; protein desuccinylation; peptidyl-lysine desuccinylation; protein deglutarylation;
	Sources:Amigo / QuickGO
Orthologs
	23408
	68346
	ENSG00000124523
	ENSMUSG00000054021
	Q9NXA8
	Q8K2C6
	NM_001193267; NM_001242827; NM_012241; NM_031244
	NM_178848
NP_001180196; NP_001229756; NP_036373; NP_112534; NP_001363727;
	NP_001363728; NP_001363729; NP_001363730; NP_001363731; NP_001363732; NP_001363733; NP_001363734; NP_001363735; NP_001363736; NP_001363737; NP_001363738; NP_001363739; NP_001363740; NP_001363741; NP_001363742; NP_001363743; NP_001363744
	NP_849179
	Wikidata
View/Edit Human	View/Edit Mouse

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the orthologous Sirt5 gene.

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and belong to the class III of the [histone deacetylase] superfamily, and are dependent on NAD+ as co-factor of enzymatic activities. SIRT5 is one of the three sirtuins localized primarily to the mitochondrion.