Sirtuin 7

SIRT7
Identifiers
Aliases	SIRT7, SIR2L7, sirtuin 7
External IDs	OMIM: 606212; MGI: 2385849; HomoloGene: 56152; GeneCards: SIRT7; OMA:SIRT7 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,921,323 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,516,066 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; granulocyte; ; monocyte; ; secondary oocyte; ; blood; ; mucosa of pharynx; ; body of stomach; ; spleen; ; skin of leg; ; right hemisphere of cerebellum;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; otic vesicle; ; thymus; ; spleen; ; right kidney; ; left lobe of liver; ; intestinal villus; ; bone marrow; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding; NAD-dependent histone deacetylase activity (H3-K18 specific); hydrolase activity; metal ion binding; NAD+ binding; histone deacetylase activity;
Cellular component	cytoplasm; nucleolus organizer region; nucleolus; nucleus;
Biological process	histone H3 deacetylation; rRNA transcription; positive regulation of transcription involved in exit from mitosis; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; histone H4 deacetylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	51547
	209011
	ENSG00000187531
	ENSMUSG00000025138
	Q9NRC8
	Q8BKJ9
	NM_016538
	NM_153056; NM_001363439
	NP_057622
	NP_694696; NP_001350368
	Wikidata
View/Edit Human	View/Edit Mouse

NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. SIRT7 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.