SIVA1

SIVA1
Identifiers
Aliases	SIVA1, CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor
External IDs	OMIM: 605567; MGI: 1353606; HomoloGene: 4692; GeneCards: SIVA1; OMA:SIVA1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	104,768,494 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	112,615,583 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; gastric mucosa; ; thoracic aorta; ; ascending aorta; ; muscle of thigh; ; anterior pituitary; ; right testis; ; left testis; ; muscle layer of sigmoid colon;
	Top expressed in
	otic placode; ; renal corpuscle; ; medullary collecting duct; ; embryo; ; embryo; ; Gonadal ridge; ; condyle; ; zygote; ; otic vesicle; ; fossa;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; virus receptor activity; tumor necrosis factor receptor binding; CD27 receptor binding;
Cellular component	cytoplasm; mitochondrion; nucleus; nucleoplasm; intracellular anatomical structure;
Biological process	apoptotic process; intrinsic apoptotic signaling pathway; viral process; activation-induced cell death of T cells; negative regulation of NF-kappaB transcription factor activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; extrinsic apoptotic signaling pathway; viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	10572
	30954
	ENSG00000184990
	ENSMUSG00000064326
	O15304
	O54926
	NM_006427; NM_021709
	NM_001161737; NM_013929
	NP_006418; NP_068355
	NP_001155209; NP_038957
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.