SIX2

SIX2
Identifiers
Aliases	SIX2, SIX homeobox 2
External IDs	OMIM: 604994; MGI: 102778; HomoloGene: 56518; GeneCards: SIX2; OMA:SIX2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	45,009,452 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,995,702 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; gastrocnemius muscle; ; parotid gland; ; muscle of thigh; ; nasal epithelium; ; tendon of biceps brachii; ; testicle; ; tibialis anterior muscle; ; palpebral conjunctiva; ; pituitary gland;
	Top expressed in
	genital tubercle; ; vestibular membrane of cochlear duct; ; maxillary prominence; ; parotid gland; ; external carotid artery; ; vestibular sensory epithelium; ; internal carotid artery; ; urethra; ; utricle; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein-containing complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	nucleus; transcription regulator complex;
Biological process	embryonic skeletal system morphogenesis; regulation of chondrocyte differentiation; regulation of transcription, DNA-templated; positive regulation of chondrocyte proliferation; chondrocyte differentiation; protein import into nucleus; kidney development; negative regulation of cell differentiation; anatomical structure morphogenesis; mesenchymal stem cell maintenance involved in nephron morphogenesis; mesenchymal to epithelial transition involved in metanephros morphogenesis; mesenchymal cell differentiation involved in kidney development; mesenchymal stem cell proliferation; transcription by RNA polymerase II; regulation of branching involved in ureteric bud morphogenesis; multicellular organism development; nephron morphogenesis; nephron development; middle ear morphogenesis; embryonic digestive tract morphogenesis; embryonic cranial skeleton morphogenesis; regulation of ossification; cell population proliferation; mesodermal cell fate specification; anterior/posterior axis specification; metanephros development; cell migration; positive regulation of transcription by RNA polymerase II; condensed mesenchymal cell proliferation; negative regulation of transcription, DNA-templated; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	10736
	20472
	ENSG00000170577
	ENSMUSG00000024134
	Q9NPC8; Q8TBA2
	Q62232
	NM_016932
	NM_011380
	NP_058628; NP_058628.3
	NP_035510
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.