SIX3

SIX3
Identifiers
Aliases	SIX3, HPE2, SIX homeobox 3
External IDs	OMIM: 603714; MGI: 102764; HomoloGene: 3947; GeneCards: SIX3; OMA:SIX3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	44,946,071 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,936,730 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; nasal epithelium; ; nucleus accumbens; ; mucosa of paranasal sinus; ; optic nerve; ; caudate nucleus; ; putamen; ; olfactory zone of nasal mucosa; ; anterior pituitary; ; buccal mucosa cell;
	Top expressed in
	optic vesicle; ; epithelium of lens; ; pretectal area; ; subthalamus; ; neural layer of retina; ; zona incerta; ; suprachiasmatic nucleus; ; optic recess; ; thalamic reticular nucleus; ; optic stalk;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; histone deacetylase binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription corepressor binding; signaling receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	nucleus; transcription regulator complex;
Biological process	eye development; forebrain anterior/posterior pattern specification; pituitary gland development; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; proximal/distal axis specification; lens fiber cell apoptotic process; protein import into nucleus; neuroblast differentiation; forebrain dorsal/ventral pattern formation; optic vesicle morphogenesis; negative regulation of Wnt signaling pathway; apoptotic process involved in development; transcription by RNA polymerase II; regulation of neural precursor cell proliferation; transcription, DNA-templated; regulation of neural retina development; multicellular organism development; telencephalon regionalization; diencephalon development; telencephalon development; brain development; lens development in camera-type eye; lens fiber cell differentiation; regulation of cell population proliferation; regulation of neuroblast proliferation; lens induction in camera-type eye; epithelial cell maturation; neuroblast migration; circadian behavior; camera-type eye development; negative regulation of transcription, DNA-templated; cell proliferation in forebrain; positive regulation of transcription by RNA polymerase II; visual perception; regulation of cell cycle phase transition; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	6496
	20473
	ENSG00000138083
	ENSMUSG00000038805
	O95343
	Q62233
	NM_005413
	NM_011381
	NP_005404
	NP_035511
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene.