SIX4

SIX4
Identifiers
Aliases	SIX4, AREC3, SIX homeobox 4
External IDs	OMIM: 606342; MGI: 106034; HomoloGene: 69089; GeneCards: SIX4; OMA:SIX4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	60,724,351 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	73,160,230 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; nasal epithelium; ; mucosa of paranasal sinus; ; cartilage tissue; ; parotid gland; ; epithelium of nasopharynx;
	Top expressed in
	lumbar spinal ganglion; ; intercostal muscle; ; maxillary prominence; ; parotid gland; ; utricle; ; foot; ; soleus muscle; ; digastric muscle; ; mandibular prominence; ; lobe of prostate;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	cytoplasm; nucleus; transcription regulator complex;
Biological process	tongue development; trigeminal ganglion development; sarcomere organization; generation of neurons; regulation of branch elongation involved in ureteric bud branching; negative regulation of apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; transcription, DNA-templated; multicellular organism development; negative regulation of satellite cell differentiation; pharyngeal system development; anatomical structure morphogenesis; embryonic skeletal system morphogenesis; inner ear morphogenesis; myotome development; fungiform papilla morphogenesis; skeletal muscle fiber differentiation; positive regulation of ureteric bud formation; regulation of gene expression; embryonic cranial skeleton morphogenesis; anatomical structure development; regulation of synaptic assembly at neuromuscular junction; olfactory placode formation; myoblast migration; thymus development; positive regulation of transcription, DNA-templated; regulation of epithelial cell proliferation; metanephric mesenchyme development; male sex determination; skeletal muscle tissue development; negative regulation of neuron apoptotic process; regulation of protein localization; male sex differentiation; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; male gonad development; negative regulation of transcription, DNA-templated; protein localization to nucleus;
	Sources:Amigo / QuickGO
Orthologs
	51804
	20474
	ENSG00000100625
	ENSMUSG00000034460
	Q9UIU6
	Q61321
	NM_017420
	NM_011382; NM_001362272
	NP_059116
	NP_035512; NP_001349201
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.