SKAP1

SKAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U5D
Identifiers
Aliases	SKAP1, HEL-S-81p, SCAP1, SKAP55, src kinase associated phosphoprotein 1
External IDs	OMIM: 604969; MGI: 1925723; HomoloGene: 2764; GeneCards: SKAP1; OMA:SKAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,430,275 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,649,956 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lobe of liver; ; right uterine tube; ; lymph node; ; blood; ; pituitary gland; ; right testis; ; left testis; ; anterior pituitary; ; right adrenal cortex;
	Top expressed in
	thymus; ; zygote; ; secondary oocyte; ; primary oocyte; ; mesenteric lymph nodes; ; blood; ; islet of Langerhans; ; seminal vesicula; ; embryo; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; SH2 domain binding; protein binding; protein phosphatase binding; protein kinase binding; protein-containing complex binding; protein homodimerization activity; microtubule plus-end binding;
Cellular component	cytoplasm; membrane; cell-cell junction; plasma membrane; T cell receptor complex; nucleus; cytosol; ruffle; immunological synapse; microtubule plus-end; plasma membrane raft;
Biological process	adaptive immune response; immune system process; positive regulation of transcription, DNA-templated; protein localization to plasma membrane; T cell receptor signaling pathway; positive regulation of cell adhesion; positive regulation of transcription by RNA polymerase II; positive regulation of signal transduction; microtubule cytoskeleton organization; positive regulation of cell-matrix adhesion; positive regulation of adaptive immune response; cell migration; positive regulation of integrin activation; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of heterotypic cell-cell adhesion; cellular response to epidermal growth factor stimulus; positive regulation of leukocyte cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	8631
	78473
	ENSG00000141293
	ENSMUSG00000057058
	Q86WV1
	Q3UUV5
	NM_001075099; NM_003726
	NM_001033186; NM_001177898; NM_001177899
	NP_001068567; NP_003717
	NP_001028358; NP_001171369; NP_001171370
	Wikidata
View/Edit Human	View/Edit Mouse

Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.

This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection and by the SKAP1 deficient mouse. Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.