SKF-81,297

SKF-81,297 is a synthetic drug of the benzazepine chemical class that acts as a selective dopamine D₁/D₅ receptor full agonist, and produces a characteristic stimulant-like pattern of anorexia, hyperactivity and self-administration in animals. This profile is shared with several related drugs such as 6-Br-APB and SKF-82,958, but not with certain other D₁ full agonists such as A-77,636, reflecting functional selectivity of D₁ activation. Newer findings reveal that SKF-81,297 additionally acts as a partial agonist at D₁-D₂ receptor heteromers.

One of the patented uses for SKF-81,297 is as an augmentation agent when combined with an appropriate choice of an antidepressant.