SKI protein

SKI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MR1, 1SBX
Identifiers
Aliases	SKI, SKI proto-oncogene, SGS, SKV
External IDs	OMIM: 164780; MGI: 98310; HomoloGene: 31124; GeneCards: SKI; OMA:SKI - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,310,213 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,307,049 bp
RNA expression pattern
	Top expressed in
	nipple; ; right hemisphere of cerebellum; ; urethra; ; decidua; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; sural nerve; ; ascending aorta; ; lower lobe of lung;
	Top expressed in
	ascending aorta; ; aortic valve; ; primary oocyte; ; secondary oocyte; ; zygote; ; ankle; ; Rostral migratory stream; ; vas deferens; ; efferent ductule; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; protein domain specific binding; histone deacetylase inhibitor activity; zinc ion binding; protein binding; SMAD binding; protein kinase binding; ubiquitin protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	PML body; centrosome; nuclear body; nucleus; nucleoplasm; transcription regulator complex; cytoplasm; transcription repressor complex; protein-containing complex;
Biological process	roof of mouth development; myotube differentiation; SMAD protein signal transduction; somatic stem cell population maintenance; nose morphogenesis; cell motility; bone morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; BMP signaling pathway; negative regulation of osteoblast differentiation; myelination in peripheral nervous system; protein homotrimerization; negative regulation of BMP signaling pathway; positive regulation of Wnt signaling pathway; negative regulation of activin receptor signaling pathway; neural tube closure; lens morphogenesis in camera-type eye; embryonic limb morphogenesis; skeletal muscle fiber development; retina development in camera-type eye; camera-type eye development; positive regulation of DNA binding; olfactory bulb development; cell population proliferation; anterior/posterior axis specification; negative regulation of fibroblast proliferation; face morphogenesis; camera-type eye morphogenesis; negative regulation of Schwann cell proliferation; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of histone deacetylation; neuron development; transforming growth factor beta receptor signaling pathway; negative regulation of cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6497
	20481
	ENSG00000157933
	ENSMUSG00000029050
	P12755
	Q60698
	NM_003036
	NM_011385; NM_001357191
	NP_003027
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The SKI protein is a nuclear proto-oncogene that is associated with tumors at high cellular concentrations. SKI has been shown to interfere with normal cellular functioning by both directly impeding expression of certain genes inside the nucleus of the cell as well as disrupting signaling proteins that activate genes.

SKI negatively regulates transforming growth factor-beta (TGF-beta) by directly interacting with Smads and repressing the transcription of TGF-beta responsive genes. This has been associated with cancer due to the large number of roles that peptide growth factors, of which TGF-beta are a subfamily, play in regulating cellular functions such as cell proliferation, apoptosis, specification, and developmental fate.

The name SKI comes from the Sloan-Kettering Institute where the protein was initially discovered.