Ileal sodium/bile acid cotransporter

SLC10A2
Identifiers
Aliases	SLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM, solute carrier family 10 member 2, Ileal bile acid transporter, PBAM1
External IDs	OMIM: 601295; MGI: 1201406; HomoloGene: 390; GeneCards: SLC10A2; OMA:SLC10A2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	103,066,417 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	5,155,351 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; duodenum; ; kidney tubule; ; testicle; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; gallbladder; ; gonad;
	Top expressed in
	proximal tubule; ; human kidney; ; right kidney; ; ileum; ; Paneth cell; ; lumbar spinal ganglion; ; left lobe of liver; ; lumbar subsegment of spinal cord; ; intestinal villus; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity; bile acid:sodium symporter activity;
Cellular component	integral component of membrane; microvillus; plasma membrane; integral component of plasma membrane; apical plasma membrane; membrane;
Biological process	ion transport; transmembrane transport; bile acid and bile salt transport; sodium ion transport; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	6555
	20494
	ENSG00000125255
	ENSMUSG00000023073
	Q12908
	P70172
	NM_000452
	NM_011388
	NP_000443
	NP_035518
	Wikidata
View/Edit Human	View/Edit Mouse

Ileal sodium/bile acid cotransporter, also known as apical sodium–bile acid transporter (ASBT) and ileal bile acid transporter (IBAT), is a bile acid:sodium symporter protein that in humans is encoded by the SLC10A2 gene.

ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.