Natural resistance-associated macrophage protein 2

SLC11A2
Identifiers
Aliases	SLC11A2, DCT1, DMT1, NRAMP2, AHMIO1, solute carrier family 11 member 2, divalent metal transporter 1, natural resistance-associated macrophage protein 2, divalent cation transporter 1
External IDs	OMIM: 600523; MGI: 1345279; HomoloGene: 55471; GeneCards: SLC11A2; OMA:SLC11A2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,028,566 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	100,322,953 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; buccal mucosa cell; ; caput epididymis; ; corpus callosum; ; cartilage tissue; ; oral cavity; ; minor salivary glands; ; superior vestibular nucleus; ; subthalamic nucleus; ; Pons;
	Top expressed in
	epithelium of small intestine; ; Ileal epithelium; ; spermatocyte; ; duodenum; ; lip; ; right kidney; ; primary oocyte; ; fetal liver hematopoietic progenitor cell; ; proximal tubule; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	vanadium ion transmembrane transporter activity; transporter activity; transition metal ion transmembrane transporter activity; lead ion transmembrane transporter activity; proton transmembrane transporter activity; cadmium ion binding; manganese ion transmembrane transporter activity; cobalt ion transmembrane transporter activity; zinc ion transmembrane transporter activity; chromium ion transmembrane transporter activity; solute:proton symporter activity; protein binding; copper ion transmembrane transporter activity; nickel cation transmembrane transporter activity; calcium ion transmembrane transporter activity; inorganic cation transmembrane transporter activity; cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; iron ion binding; copper ion binding; zinc ion binding; nickel cation binding; manganese ion binding; metal ion transmembrane transporter activity; cobalt ion binding;
Cellular component	cytoplasm; endosome; membrane; basal part of cell; retromer complex; trans-Golgi network; perinuclear region of cytoplasm; nucleus; late endosome membrane; cell surface; mitochondrial outer membrane; apical plasma membrane; lysosome; integral component of membrane; recycling endosome; late endosome; plasma membrane; apical part of cell; early endosome; brush border; endosome membrane; paraferritin complex; integral component of plasma membrane; brush border membrane; lysosomal membrane; vacuole; cytoplasmic vesicle; endomembrane system; mitochondrion; extracellular vesicle;
Biological process	cadmium ion transmembrane transport; activation of cysteine-type endopeptidase activity involved in apoptotic process; proton transmembrane transport; lead ion transport; iron ion homeostasis; ion transport; heme biosynthetic process; multicellular organismal iron ion homeostasis; learning or memory; iron ion transmembrane transport; dendrite morphogenesis; porphyrin-containing compound biosynthetic process; response to iron ion; iron ion transport; copper ion transport; response to hypoxia; cobalt ion transport; detection of oxygen; cellular response to oxidative stress; manganese ion transport; nickel cation transport; erythrocyte development; porphyrin-containing compound metabolic process; cellular iron ion homeostasis; cation transmembrane transport; manganese ion transmembrane transport; vanadium ion transport; zinc ion transmembrane transport; nickel cation transmembrane transport; copper ion transmembrane transport; transport; metal ion transport; iron import into cell;
	Sources:Amigo / QuickGO
Orthologs
	4891
	18174
	ENSG00000110911
	ENSMUSG00000023030
	P49281
	P49282
NM_000617; NM_001174125; NM_001174126; NM_001174127; NM_001174128;
	NM_001174129; NM_001174130; NM_001379446; NM_001379447; NM_001379448; NM_001379455
	NM_001146161; NM_008732; NM_001356952
NP_000608; NP_001167596; NP_001167597; NP_001167598; NP_001167599;
	NP_001167600; NP_001167601; NP_001366375; NP_001366376; NP_001366377; NP_001366384
	NP_001139633; NP_032758; NP_001343881
	Wikidata
View/Edit Human	View/Edit Mouse

Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.

As its name suggests, DMT1 binds a variety of divalent metals including cadmium (Cd²⁺), copper (Cu²⁺), and zinc (Zn^2+,); however, it is best known for its role in transporting ferrous iron (Fe²⁺). DMT1 expression is regulated by body iron stores to maintain iron homeostasis. DMT1 is also important in the absorption and transport of manganese (Mn²⁺). In the digestive tract, it is located on the apical membrane of enterocytes, where it carries out H⁺-coupled transport of divalent metal cations from the intestinal lumen into the cell.