SLC12A6

SLC12A6
Identifiers
Aliases	SLC12A6, ACCPN, KCC3, KCC3A, KCC3B, solute carrier family 12 member 6
External IDs	OMIM: 604878; MGI: 2135960; HomoloGene: 21069; GeneCards: SLC12A6; OMA:SLC12A6 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	34,338,060 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	112,193,508 bp
RNA expression pattern
	Top expressed in
	blood; ; secondary oocyte; ; trabecular bone; ; sperm; ; mucosa of pharynx; ; monocyte; ; oral cavity; ; gums; ; Pons; ; gingival epithelium;
	Top expressed in
	granulocyte; ; neural layer of retina; ; transitional epithelium of urinary bladder; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; spleen; ; blood; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cation:chloride symporter activity; transporter activity; potassium ion transmembrane transporter activity; symporter activity; protein kinase binding; potassium:chloride symporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; basolateral plasma membrane;
Biological process	cellular hypotonic salinity response; cellular hypotonic response; chloride transmembrane transport; ion transport; potassium ion transport; angiogenesis; chemical synaptic transmission; potassium ion transmembrane transport; transmembrane transport; cell volume homeostasis; chloride ion homeostasis; potassium ion homeostasis; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9990
	107723
	ENSG00000140199
	ENSMUSG00000027130
	Q9UHW9
	Q924N4
NM_001042494; NM_001042495; NM_001042496; NM_001042497; NM_005135;
	NM_133647; NM_001365088
	NM_133648; NM_133649; NM_001362700
NP_001035959; NP_001035960; NP_001035961; NP_001035962; NP_005126;
	NP_598408; NP_001352017
	NP_598409; NP_598410; NP_001349629
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 12 member 6 is a protein that in humans is encoded by the SLC12A6 gene.

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms, the most important ones being KCC3a and KCC3b. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.