Vesicular glutamate transporter 1

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208; MGI: 1920211; HomoloGene: 113454; GeneCards: SLC17A7; OMA:SLC17A7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,442,360 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,825,566 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; superior frontal gyrus; ; Brodmann area 10; ; frontal pole; ; Region I of hippocampus proper; ; middle temporal gyrus; ; Brodmann area 46; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; prefrontal cortex; ; piriform cortex; ; cerebellar cortex; ; hippocampus proper; ; primary motor cortex; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	inorganic phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; extracellularly glutamate-gated chloride channel activity; symporter activity; L-glutamate transmembrane transporter activity; neurotransmitter transmembrane transporter activity;
Cellular component	postsynapse; integral component of membrane; membrane; synaptic vesicle; plasma membrane; synapse; excitatory synapse; synaptic vesicle membrane; cerebellar mossy fiber; presynaptic active zone; cell junction; intracellular organelle; neuron projection; clathrin-sculpted glutamate transport vesicle membrane; cytoplasmic vesicle; integral component of synaptic vesicle membrane;
Biological process	phosphate ion transport; synaptic transmission, glutamatergic; sodium-dependent phosphate transport; sodium ion transport; chloride transmembrane transport; ion transport; glutamate secretion; synaptic vesicle lumen acidification; brain development; long-term memory; excitatory postsynaptic potential; neurotransmitter transport; neural retina development; L-glutamate import; sequestering of neurotransmitter; sodium ion transmembrane transport; transmembrane transport; chemical synaptic transmission; neurotransmitter loading into synaptic vesicle; L-glutamate transmembrane transport; regulation of synaptic vesicle endocytosis; regulation of synapse structure or activity;
	Sources:Amigo / QuickGO
Orthologs
	57030
	72961
	ENSG00000104888
	ENSMUSG00000070570
	Q9P2U7
	Q3TXX4
	NM_020309
	NM_182993
	NP_064705
	NP_892038
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.