Excitatory amino acid transporter 4

SLC1A6
Identifiers
Aliases	SLC1A6, EAAT4, solute carrier family 1 member 6
External IDs	OMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,022,990 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	78,650,599 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; endothelial cell; ; left testis; ; right testis; ; paraflocculus of cerebellum; ; skin of thigh; ; cerebellar vermis; ; nucleus accumbens; ; oocyte; ; caudate nucleus;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; dorsomedial hypothalamic nucleus; ; lumbar subsegment of spinal cord; ; ventromedial nucleus; ; inferior colliculi; ; superior colliculus; ; dentate gyrus of hippocampal formation granule cell; ; lateral hypothalamus; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	L-aspartate transmembrane transporter activity; symporter activity; L-glutamate transmembrane transporter activity; amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; metal ion binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; intermediate filament cytoskeleton; integral component of plasma membrane; plasma membrane; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	chemical synaptic transmission; regulation of membrane potential; ion transport; glutamate secretion; aspartate transmembrane transport; L-glutamate transmembrane transport; L-glutamate import across plasma membrane; amino acid transport; L-aspartate transmembrane transport; neurotransmitter uptake; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6511
	20513
	ENSG00000105143
	ENSMUSG00000005357
	P48664
	O35544
NM_001272087; NM_001272088; NM_005071; NM_001384669; NM_001384670;
	NM_001384671
	NM_009200
	NP_001259016; NP_001259017; NP_005062
	NP_033226
	Wikidata
View/Edit Human	View/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.