SLC22A2

SLC22A2
Identifiers
Aliases	SLC22A2, OCT2, solute carrier family 22 member 2
External IDs	OMIM: 602608; MGI: 1335072; HomoloGene: 68293; GeneCards: SLC22A2; OMA:SLC22A2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	160,277,638 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	12,847,375 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; renal medulla; ; human kidney; ; testicle; ; glomerulus; ; metanephric glomerulus; ; buccal mucosa cell; ; oocyte; ; secondary oocyte; ; right coronary artery;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; yolk sac; ; proximal convoluted tubule; ; proximal straight tubule; ; respiratory epithelium; ; olfactory epithelium; ; sciatic nerve; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter activity; transporter activity; neurotransmitter transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; organic cation transmembrane transporter activity; acetylcholine transmembrane transporter activity; norepinephrine:sodium symporter activity; secondary active organic cation transmembrane transporter activity; organic anion transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular exosome; integral component of plasma membrane; presynapse;
Biological process	xenobiotic transmembrane transport; body fluid secretion; quaternary ammonium group transport; neurotransmitter biosynthetic process; cation transport; ion transport; dopamine transport; neurotransmitter secretion; organic cation transport; transmembrane transport; ammonium transmembrane transport; neurotransmitter transport; organic anion transport; norepinephrine transport; acetate ester transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6582
	20518
	ENSG00000112499
	ENSMUSG00000040966
	O15244
	O70577
	NM_153191; NM_003058
	NM_013667; NM_001355767
	NP_003049
	NP_038695; NP_001342696
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2) is a protein that in humans is encoded by the SLC22A2 gene.

Poly specific organic cation transporters in the liver, kidney, intestine, and other organs are important for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.